科研项目 |
1.国家自然科学基金委员会,地区基金项目,82060503,去甲基化酶JMJD6通过调控自噬和凋亡来影响BRAF突变型黑色素瘤耐药性的机制研究,2021-01至2024-12,35万,在研,主持 2.国家自然科学基金委员会,青年基金项目,31701007,单倍体胚胎干细胞与神经母细胞瘤共培养的体内外抗肿瘤作用研究,2018-01至2020-12,24万,结题,主持 3.贵州省科技厅,贵州省科技计划项目(课题),黔科合基础-ZK[2022]一般622,BRAF突变型黑色素瘤耐药相关甲基化差异分析,2022-04至2025-03,10万,在研,主持 4.贵州省科技厅,贵州省科技计划项目(课题),黔科合基础[2019]1334号,NAMPT/E2F2/SIRT1信号轴表观调控黑色素瘤细胞增殖和代谢的分子机制研究,2019-01至2021-12,10万,在研,主持 5.贵州省卫生健康委员会,卫健委科学技术基金项目,gzwjkj2019-1-033,白藜芦醇调控NRAS突变型黑色素瘤细胞增殖与转移的分子机制研究,2020-01至2021-12,4万,在研,主持 6.贵州省教育厅,青年科技人才成长项目,黔教合KY字[2017]198,沉默信息调节因子2相关酶1(SIRT1)调控单倍体胚胎干细胞染色体二倍体化的分子机制研究,2017-11至2020-10,6万,结题,主持 |
发表论文 |
1. Limin Han, Qiang Fu, Chuan Deng, Li Luo, Tengxiao Xiang, Hailong Zhao, Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour, Scandinavian Journal of Immunology, 2022, 95(1): e13106. 2. Hailong Zhao, Shuaicai Xiong, Zhiwei Li, Xuebiao Wu, Lijuan Li, Meta-analytic Method Reveal a Significant Association of the BDNF Val66Met Variant With Smoking Persistence Based on a Large Samples, The Pharmacogenomics Journal, 2020, 20(3): 398-407. 3. Hailong Zhao, Limin Han, Yi Jian, Yuntao Ma, Wanyue Yan, Xiaowen Chen, Haiyan Xu, Lijuan Li,Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis, OncoTargets and Therapy, 2018, 11: 8995-9006. 4. Hailong Zhao, Weiwei Tang, Xiaowen Chen, Siyuan Wang, Xianyan Wang, Haiyan Xu, Lijuan Li,The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells, Biochemical and Biophysical Research Communications, 2017, 493(1): 77-84. 5.韩利民,严婉约,李巧巧,李科,刘丽,赵海龙,不同浓度米诺环素对人胶质瘤细胞增殖、自噬、凋亡的影响及其机制,天津医药, 2020, (9): 801-806+913. |